SYNTHESIS OF THE 2-BETA,3-ALPHA-ISOMERS AND 2-BETA,3-BETA-ISOMERS OF 3-(P-SUBSTITUTED PHENYL)TROPANE-2-CARBOXYLIC ACID METHYL-ESTERS

Authors
KEVERLINE KI ABRAHAM P LEWIN AH CARROLL FI
Citation
Ki. Keverline et al., SYNTHESIS OF THE 2-BETA,3-ALPHA-ISOMERS AND 2-BETA,3-BETA-ISOMERS OF 3-(P-SUBSTITUTED PHENYL)TROPANE-2-CARBOXYLIC ACID METHYL-ESTERS, Tetrahedron letters, 36(18), 1995, pp. 3099-3102
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
18
Year of publication
1995
Pages
3099 - 3102
Database
ISI
SICI code
0040-4039(1995)36:18<3099:SOT2A2>2.0.ZU;2-0
Abstract
The synthesis of 3-(p-substituted phenyl)trop-2-ene-2-carboxylic acid methyl ester 8 and its reduction with samarium iodide provide a new sy nthesis of 3 beta-(4'-substituted phenyl)tropane-2 beta-carboxylic aci d methyl ester (2) and, in addition, give the first synthesis of the 2 beta,3 alpha-diastereoisomer 4.