REGIOSPECIFIC BROMINATION OF 3-METHYLINDOLES WITH N-BROMOSUCCINIMIDE

Authors
ZHANG PW LIU RY COOK JM
Citation
Pw. Zhang et al., REGIOSPECIFIC BROMINATION OF 3-METHYLINDOLES WITH N-BROMOSUCCINIMIDE, Tetrahedron letters, 36(18), 1995, pp. 3103-3106
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
18
Year of publication
1995
Pages
3103 - 3106
Database
ISI
SICI code
0040-4039(1995)36:18<3103:RBO3WN>2.0.ZU;2-Q
Abstract
The regiospecific bromination of various substituted 3-methylindoles a t either C(2) or the C(3) alkyl moiety was accomplished via an electro philic or free radical bromination process to provide intermediates fo r indole alkaloid total synthesis. The regiospecificity of the bromina tion could be controlled by variation of both the substituent and the N(1) protecting group on the indole ring.