COMPARATIVE PHOTOPHYSICAL STUDY OF DISULFONATED ALUMINUM PHTHALOCYANINE IN UNILAMELLAR VESICLES AND LEUKEMIC K562 CELLS

Authors
DHAMI S RUMBLES G MACROBERT AJ PHILLIPS D
Citation
S. Dhami et al., COMPARATIVE PHOTOPHYSICAL STUDY OF DISULFONATED ALUMINUM PHTHALOCYANINE IN UNILAMELLAR VESICLES AND LEUKEMIC K562 CELLS, Photochemistry and photobiology, 65(1), 1997, pp. 85-90
Citations number
23
Categorie Soggetti
Biophysics,Biology
Journal title
Photochemistry and photobiology → ACNP
ISSN journal
00318655
Volume
65
Issue
1
Year of publication
1997
Pages
85 - 90
Database
ISI
SICI code
0031-8655(1997)65:1<85:CPSODA>2.0.ZU;2-B
Abstract
The photophysical properties of cis-disulfonated aluminum phthalocyani ne (AlPcS(2)) in unilamellar vesicles (liposomes) of DL-alpha-dipalmit oyl-phosphatidylcholine have been measured, Both the fluorescence and triplet quantum yields decreased with increasing sensitizer concentrat ion, The time-resolved fluorescence decays, analysed by both the sum o f exponentials and decay time distribution analyses, are compared with those reported for AlPcS(2) in leukemic K562 cells. Information on th e photodynamic transport and localization mechanism has been obtained by drawing correlations between the two systems, indicating active tra nsport of the phthalocyanine into tumor cells involving lysosomal accu mulation.