PHOTOREPAIR OF ULTRAVIOLET-RADIATION (UVR)-INDUCED PYRIMIDINE DIMERS IN LENS EPITHELIAL DNA OF MONODELPHIS-DOMESTICA

Authors
TAFOYA GB GALE JM LEY RD
Citation
Gb. Tafoya et al., PHOTOREPAIR OF ULTRAVIOLET-RADIATION (UVR)-INDUCED PYRIMIDINE DIMERS IN LENS EPITHELIAL DNA OF MONODELPHIS-DOMESTICA, Photochemistry and photobiology, 65(1), 1997, pp. 125-128
Citations number
25
Categorie Soggetti
Biophysics,Biology
Journal title
Photochemistry and photobiology → ACNP
ISSN journal
00318655
Volume
65
Issue
1
Year of publication
1997
Pages
125 - 128
Database
ISI
SICI code
0031-8655(1997)65:1<125:POU(PD>2.0.ZU;2-N
Abstract
The repair of UV radiation-induced pyrimidine dimers has been measured in lens epithelial DNA of the marsupial Monodelphis domestica using a pyrimidine dimer-specific endonuclease from Micrococcus luteus. Appro ximately 40% of the initially induced dimers were repaired during 90 m in exposures to photoreactivating light. This capacity of the lens epi thelium to photorepair pyrimidine dimers may provide a means with whic h to determine whether pyrimidine dimers in lens epithelial DNA are in volved in UV radiation-induced pathologic changes of the lens.