NODULAR PRURIGO RESPONDS TO CYCLOSPORINE

Nodular prurigo is a distressing disease which is difficult to treat. Two patients with severe nodular prurigo were treated with cyclosporin for periods of 36 and 24 weeks, respectively, using doses of 3-4.5 mg /kg per day. In both cases there was a reduction in the severity of pr uritus after 2 weeks of treatment, In one patient there was a consider able, although incomplete response, and in the other almost complete r esolution of the disease was achieved. The improvement was maintained throughout the treatment period, and the drug was generally well toler ated, although in one patient there was a rise in serum creatinine dur ing treatment, which later returned to normal.