ENHANCEMENT IN GASTRIC-MUCOSAL EGF AND PDGF RECEPTOR EXPRESSION WITH ULCER HEALING BY SULGLYCOTIDE

1. The effect of an antiulcer agent, sulglycotide, on mucosal expressi on of EGF and PDGF receptors with chronic ulcer healing was investigat ed. 2. Rats with experimentally-induced gastric ulcers were treated tw ice daily for 14 consecutive days, either with sulglycotide at 200 mg/ kg or vehicle, and at different stages of treatment used for quantitat ion of gastric mucosal EGF and PDGF receptors. 3. The ulcer healing wa s accompanied by an increase in mucosal expression of both types of re ceptors. A 1.8-fold increase in EGF and 3.1-fold increase in PDGF rece ptors occurred by the 4th day following the development of ulcer and r eached a maximum of 2.4-3.9-fold increase by the 10-14th day. 4. Treat ment with sulglycotide caused accelerated ulcer healing accompanied by a significant enhancement in the receptors expression. A 2.3- and 3.6 -fold increase in EGF and PDGF receptor expression occurred by the 4th day of sulglycotide treatment, reaching a 5.5- and 5.6-fold respectiv e increase by the 10th day when the ulcer essentially healed. 5. The r esults attest to the ability of sulglycotide to stimulate the gastric mucosal proliferative activities associated with ulcer healing.