CONSTITUTIONAL TRISOMY-8 MOSAICISM AND GESTATIONAL TROPHOBLASTIC DISEASE

Concurrence of congenital trisomy 8 mosaicism and gestational trophobl astic disease in a 48-year-old gravida IV, para IV female is described in the present report. In contrast to other cases described in the li terature, our patient had no known additional confounding chromosomal abnormalities other than trisomy 8. The finding of trisomy 8 mosaicism in yet another type of cancer provides further support for the hypoth esis of an increased predisposition to cancer in tissues with constitu tional genomic imbalance, which can manifest itself os numerical chrom osomal abnormalities (e.g., trisomies) or structural chromosomal abnor malities (e.g., translocations). To the best of our knowledge, this is the only report in the English literature of constitutional trisomy 8 mosaicism associated with gestational trophoblastic disease, a rare g ynecologic disease entity in itself.