THE VALUE OF DIFFERENT RESISTANCE PARAMETERS IN DISTINGUISHING BIOPSY-PROVED DYSFUNCTION OF RENAL-ALLOGRAFTS

The data concerning the value of duplex sonography in diagnosing paren chymatous renal allograft dysfunction are controversial. Most early st udies did not take into consideration the many factors influencing res istance parameters. We therefore performed a prospective, biopsy-contr olled study with exclusion of all known sources of error regarding res istance parameters. Furthermore we investigated the value of a new res istance parameter, the systolic deceleration percentage. Forty-seven d uplex sonographic studies were performed on 43 patients (30 male, 13 f emale, median age 47 years, range 7-70). Fourteen studies were done on normally functioning grafts (control group) an average of 33 days aft er transplantation. Thirty-three studies were performed on dysfunction al grafts immediately prior to biopsy. Grafts which had been transplan ted more than a year previously or with vascular findings or any other clinical or sonographic pathology probably explaining function deteri oration were excluded. In all patients, the resistive index (RI), puls atility index (PI) and systolic deceleration percentage (DP) were calc ulated in the main renal artery and in the interlobar artery. Of the 3 3 grafts with dysfunction, nine had vascular rejection (VR), 11 inters titial rejection (IR), 11 cyclosporin A toxicity (CAT) and two other h istologies (OR). The mean RI in normal grafts (NO) was 0.71+/-0.06 in the main artery and 0.68+/-0.06 in the interlobar artery, in VR 0.86+/ -0.12 and 0.80+/-0.18, in IR 0.72+/-0.05 and 0.70+/-0.07, in CAT 0.67/-0.06 and 0.65+/-0.07 and in OR 0.64+/-0.07 and 0.60+/-0.01. For PI, the values were 1.45+/-0.23 and 1.41+/-0.28 (NO), 3.5+/-2.13 and 2.92/-2.16 (VR), 1.55+/-0.26 and 1.46+/-0.33 (IR), 1.32+/-0.25 and 1.27+/- 0.26 (CAT) and 1.30+/-0.34 and 1.13+/-0.04 (OR). For DP we calculated 28+/-5% and 29+/-6% (NO), 43+/-14% and 36+/-6% (VR), 29+/-9% and 27+/- 9% (IR), 31+/-8% and 32+/-7% (CAT) and 32+/-4% and 28+/-3% (OR). The s ensitivity/specificity for VR with a cutoff mean +2 SD was 0.44/1 for RI, 0.55/0.97 for PI and 0.33/0.89 for DP. It was concluded that: (1) despite the high selection of our patient group, diagnostic accuracy o f duplex sonography for diagnosing parenchymatous function disorder in renal allograft remains insufficient; (2) in vascular rejection only, the resistance parameters differ significantly from the values of nor mal allografts; (3) the higher the cutoff of resistance parameters, th e better the specificity and the worse the sensitivity for diagnosing vascular rejection; (4) of all investigated resistance parameters, the RI is the most practical due to a simple measurement technique.