MOCLOBEMIDE AND SPECIFIC SEROTONIN REUPTAKE INHIBITOR COMBINATION TREATMENT OF RESISTANT ANXIETY AND DEPRESSIVE-DISORDERS

This retrospective study was undertaken with the objective of determin ing how effective and safe moclobemide, a specific and reversible inhi bitor of monoamine oxidase-A (RIMA), is when used in combination with specific serotonin re-uptake inhibitors (SSRIs), in a clinical setting . A thorough chart review was done of all patients with affective and anxiety disorders seen at our centre who received combination treatmen t with moclobemide and an SSRI. Combination moclobemide-SSRI treatment demonstrated good efficacy in treating treatment-resistant patients. The combination treatment was well tolerated with very few drug intera ctions. Dosages should be started low, titrated slowly and carefully, and patients should be monitored closely.