NEUROPROTECTIVE EFFECT OF SELENIUM ON IMINODIPROPIONITRILE-INDUCED TOXICITY

The present investigation was undertaken to study the effect of seleni um on experimental dyskinesia in rats. The movement disorders were pro duced in rats by intraperitoneal administration of iminodipropionitril e (IDPN) in the dose of 100 mg/kg per day for 12 days. Selenious acid was administered daily 30 minutes before IDPN in the doses of 5 mu mol /kg, 10 mu mol/kg and 20 mu mol/kg bodyweight in three different group s of rats. Animals were observed daily for any neurobehavioral changes including circling, backwalking, head weaving and twitching. Immediat ely after behavioral studies, blood and brain specimens were collected for analysis of thiobarbituric acid reactive substances (TEARS) to me asure the extent of free radical production. Our results showed that c oncurrent use of selenium significantly inhibited IDPN-induced neurobe havioral changes in a dose-dependent manner. Treatment of rats with se lenium also reduced the TEARS production in blood and different region s of brain. These findings suggest that selenium attenuates the IDPN-i nduced neurotoxicity by inhibiting lipid peroxidation.