ASPECTS OF THE DESIGN AND DELIVERY OF MICROPARTICLES FOR VACCINE APPLICATIONS

Mortality and morbidity data continue to indicate there is a compellin g need for the derivation of a new generation of vaccine delivery syst ems that can be usefully applied via injection and also mucosally One technology that has potential for design as an effective vaccine deliv ery system is the formulation of biodegradable microparticles from the polymers and poly lactide co-glycolide (PLGA) in particular. The pote ntial advantages of the delivery of vaccines within such microparticle s is discussed. The potential for eliciting and optimising immunity af ter the mucosal delivery of biodegradable microparticles is also discu ssed.