Jr. Alexander et al., FREQUENCY OF POSITIVE FAMILY HISTORY IN BIPOLAR PATIENTS IN A CATCHMENT-AREA POPULATION, Progress in neuro-psychopharmacology & biological psychiatry, 19(3), 1995, pp. 367-373
1. Major family studies of bipolar disorder report the frequency of af
fective disorder among probands' relatives, but do not usually report
the frequency of a positive family history among probands. A single pr
evious study was not population based. 2. The Division of Psychiatry o
f Ben Gurion University provides virtually all psychiatric services fo
r a catchment area of 300,000 people. The authors reviewed the charts
of all 236 treated bipolar I patients in 1991, and interviewed 177 of
them with a modified FH-RDC. 3. 48% of probands had a family history o
f mental illness. 4. However, the present methods of ascertainment may
have been insufficiently sensitive.