2 CATEGORIES OF SYNOVIAL SARCOMA DEFINED BY DIVERGENT CHROMOSOME-TRANSLOCATION BREAKPOINTS IN XP11.2, WITH IMPLICATIONS FOR THE HISTOLOGIC SUB-CLASSIFICATION OF SYNOVIAL SARCOMA

Authors
RENWICK PJ REEVES BR DALCIN P FLETCHER CDM KEMPSKI H SCIOT R KAZMIERCZAK B JANI K SONOBE H KNIGHT JC
Citation
Pj. Renwick et al., 2 CATEGORIES OF SYNOVIAL SARCOMA DEFINED BY DIVERGENT CHROMOSOME-TRANSLOCATION BREAKPOINTS IN XP11.2, WITH IMPLICATIONS FOR THE HISTOLOGIC SUB-CLASSIFICATION OF SYNOVIAL SARCOMA, Cytogenetics and cell genetics, 70(1-2), 1995, pp. 58-63
Citations number
11
Categorie Soggetti
Cell Biology","Genetics & Heredity
Journal title
Cytogenetics and cell genetics → ACNP
ISSN journal
03010171
Volume
70
Issue
1-2
Year of publication
1995
Pages
58 - 63
Database
ISI
SICI code
0301-0171(1995)70:1-2<58:2COSSD>2.0.ZU;2-A
Abstract
Molecular analysis of a new series of synovial sarcomas confirms that t(X;18)(p11.2;q11.2) breakpoints occur at two distinct regions on Xp d esignated SS1 and SS2. Breakpoint position correlates with tumor pheno type. Monophasic tumors with no evidence of glandular components have breakpoints within the SS2 region in Xp11.21, and biphasic tumors with a focal poorly differentiated or extensive glandular structure have b reakpoints within the SS1 region in Xp11.23.