Synthesis of new isoxazolo[4,5-d]pyrimidine derivatives is reported. S
ome of isoxazolo[4,5-d]pyrimidine derivatives were tested for anticonv
ulsant, anxiolytic and antiserotonine activity. Compounds 14 and 16 pr
oved active against hypothermia induced by reserpine and hyperthermia
induced by m-CPP.