POOR INTERACTION OF SOME QUINOLIZIDINE DERIVATIVES WITH DOPAMINE D-1-TYPE AND D-2-TYPE RECEPTORS

The displacement of [H-3]SCH-23390 and of [H-3]spiperone from striatal , dopamine D-1- and D-2-type receptors by several quinolizidinyl-deriv atives of bi- and tricyclic systems was investigated. All tested compo unds did not affect SCH-23390 binding and exhibited only weak activity On spiperone binding to D, binding sites (K-i = 1-9 mu M). Therefore the good deconditioning activity (CAR blockade in rats) of 6-chloro-1- lupinyl-3-methyl-quinoxalinone (18) must rely on interactions with oth er kinds of receptors.