EFFECT OF TIME-INTERVAL ON TISSUE CONCENTRATIONS OF CEPHALOSPORINS AFTER TOURNIQUET INFLATION - HIGHEST LEVELS ACHIEVED BY ADMINISTRATION 20 MINUTES BEFORE INFLATION

Authors
DOUNIS E TSOURVAKAS S KALIVAS L GIAMACELLOU H
Citation
E. Dounis et al., EFFECT OF TIME-INTERVAL ON TISSUE CONCENTRATIONS OF CEPHALOSPORINS AFTER TOURNIQUET INFLATION - HIGHEST LEVELS ACHIEVED BY ADMINISTRATION 20 MINUTES BEFORE INFLATION, Acta orthopaedica Scandinavica, 66(2), 1995, pp. 158-160
Citations number
6
Categorie Soggetti
Orthopedics
Journal title
Acta orthopaedica Scandinavica → ACNP
ISSN journal
00016470
Volume
66
Issue
2
Year of publication
1995
Pages
158 - 160
Database
ISI
SICI code
0001-6470(1995)66:2<158:EOTOTC>2.0.ZU;2-Z
Abstract
We studied the effect of different time intervals between antibiotic a dministration and tourniquet inflation in 62 patients undergoing recon structive surgery in the lower extremities. The in vivo concentrations in soft tissue and bone of 3 cephalosporins (ceftazidime, ceftriaxone and ceforanide) were determined. Our findings suggest that the highes t tissue concentrations were achieved by administration 20 min before tourniquet inflation.