W. Lange et al., CECUM OF GUINEA-PIG IS A RESERVOIR AND SIGMOID IS A HIGH-RESISTANCE CONDUIT, Digestive diseases and sciences, 40(5), 1995, pp. 1015-1023
We compared the filling responses of the cecum and the sigmoid of the
guinea pig using volumes up to 60 ml and 2.5 ml, respectively. In the
isolated cecum, each l-cm increment of hydrostatic pressure above zero
led to accommodation of 10 ml volume; in the sigmoid, the yield press
ure (at which accommodation first occurred) was 6 cm H2O, and pressure
increments up to 20 cm H2O produced volume increments of less than 0.
5 ml. Resting pressure at half-maximal filling was 5.0 +/- 0.7 cm H2O
for the sigmoid and 1.7 +/- 0.6 cm H2O for the cecum. K+ depolarizatio
n led to a significant upward shift in the pressure curves of both seg
ments. Ca2+ withdrawal decreased sigmoid and cecal pressures at some v
olumes. Distension of the cecum triggered intermittent contractions, w
hich began with the shortening of the teniae and were associated with
low-amplitude pressures and expulsion of a 5- to 10-ml volume. Distens
ion of the sigmoid produced propagating contractions that were associa
ted with high-amplitude pressures and lengthening; compartmentalizatio
n in the sigmoid prevented efflux from it, and volume inflow was not a
ffected by pressure waves. Our observations indicate that its large ca
pacity and great distensibility make the cecum suitable for reservoir
functions, whereas its narrowness and lack of distensibility make the
sigmoid a high-resistance conduit.