DECREASE OF D-LOOP FREQUENCY IN HEART AND CEREBRAL HEMISPHERES MITOCHONDRIAL-DNA OF AGED RAT

Authors
PETRUZZELLA V FRACASSO F GADALETA MN CANTATORE P
Citation
V. Petruzzella et al., DECREASE OF D-LOOP FREQUENCY IN HEART AND CEREBRAL HEMISPHERES MITOCHONDRIAL-DNA OF AGED RAT, Molecular and chemical neuropathology, 24(2-3), 1995, pp. 193-202
Citations number
32
Categorie Soggetti
Pathology,Neurosciences
Journal title
Molecular and chemical neuropathology → ACNP
ISSN journal
10447393
Volume
24
Issue
2-3
Year of publication
1995
Pages
193 - 202
Database
ISI
SICI code
1044-7393(1995)24:2-3<193:DODFIH>2.0.ZU;2-K
Abstract
A quantitative analysis of the frequency of the supercoiled mitochondr ial DNA molecules containing the D-loop in rat heart and cerebral hemi spheres, at different ages, is presented. Both tissues of aged animals exhibit a remarkable reduction in the content of supercoiled D-loop c ontaining molecules compared to the adults. This alteration could be r esponsible for the age-dependent reduction of mitochondrial DNA transc ription previously observed in rat brain and heart.