Pleuropneumonia is a clinically important equine disease, predisposed
by a number of identifiable factors. Successful management is largely
dependent on early identification and prompt initiation of appropriate
treatment strategies. Rapid resolution of the disease process is asso
ciated with appropriate treatment commenced within 48 h of the causati
ve insult. Lower airway contamination by oropharyngeal organisms and s
ubsequent extension into the pulmonary parenchyma results in respirato
ry dysfunction and systemic toxaemia. Acute disease is associated with
the isolation of facultatively anaerobic organisms, especially beta-h
aemolytic Streptococcus spp. and Pasteurellaceae. Delayed or inappropr
iate treatment is likely to result in chronic disease characterized by
the involvement of anaerobic bacteria and a poor response to therapy.
The primary mode of treatment for anaerobic infection of the human th
orax is surgical drainage and resection of necrotic tissue but whilst
such techniques have been described for the management of equine pleur
opneumonia, the size of the equine thoracic cavity hinders accurate di
agnostic evaluation and successful completion of such intervention. Th
e chronic nature and cost of ongoing treatment and limitations on choi
ce of antimicrobial agents warrant a poor prognosis for survival and a
poorer prognosis for return to athletic endeavour.