Xw. Li et al., CYTOPLASMIC EXPRESSION OF P53 PROTEIN AND ITS MORPHOLOGICAL FEATURES IN SALIVARY-GLAND LESIONS, Journal of oral pathology & medicine, 24(5), 1995, pp. 201-205
An immunohistochemical study of p53 protein was carried out on 45 sali
vary gland lesions using a monoclonal antibody, Bp53-12, raised to the
intracellular domain of the p53 protein. p53 protein expression was f
ound in 34.4% of 32 salivary gland carcinomas. Nuclear p53 expression
was detected in tumor cells but not in non-neoplastic cells, except in
one salivary duct carcinoma. The perinuclear cytoplasm of luminal duc
t cells was specifically positive for the antibody used here. Cytoplas
mic p53 expression was observed mostly in non-neoplastic cells. There
was a tendency for the cytoplasmic staining of p53 protein to be obser
ved in the normal cells adjacent to p53-positive carcinomas, but none
of the normal cells were positive in the tissues surrounding p53-negat
ive carcinomas. Cytoplasmic expression of p53 protein in salivary glan
d tissues seems to be correlated with tumorigenesis.