Many potential causes of renal transplant dysfunction are accurately a
nd noninvasively diagnosed by sonograpy. Gray scale sonography may ide
ntify hydronephrosis and perinephric fluid collections. Screening of v
ascular complications of renal transplantation is easily performed usi
ng color and duplex Doppler sonography. Initial studies emphasizing th
e ability of sonography to noninvasively discriminate between acute re
jection and other causes of transplant dysfunction (acute tubular necr
osis, cyclosporine toxicity) have largely been discounted. Nonetheless
, ultrasound may still play a pivotal role in differentiating between
intrinsic causes of graft dysfunction by providing guidance for defini
te percutaneous renal biopsy.