PHOTODYNAMIC-ACTION INCREASES LEAKAGE OF THE MITOCHONDRIAL ELECTRON-TRANSPORT CHAIN

Authors
SALET C MORENO G
Citation
C. Salet et G. Moreno, PHOTODYNAMIC-ACTION INCREASES LEAKAGE OF THE MITOCHONDRIAL ELECTRON-TRANSPORT CHAIN, International journal of radiation biology, 67(4), 1995, pp. 477-480
Citations number
16
Categorie Soggetti
Radiology,Nuclear Medicine & Medical Imaging","Nuclear Sciences & Tecnology
Journal title
International journal of radiation biology → ACNP
ISSN journal
09553002
Volume
67
Issue
4
Year of publication
1995
Pages
477 - 480
Database
ISI
SICI code
0955-3002(1995)67:4<477:PILOTM>2.0.ZU;2-Y
Abstract
Rat liver submitochondrial particles were treated with rose bengal or flavin mononucleotide and irradiated with visible or near UV light. In both cases, oxygen consumption is impaired after irradiation while O- 2(.-) production increases significantly. This suggests that exogenous or endogenous photosensitizers can induce more electron leakage in th e mitochondrial respiratory chain. Photobiological implications in der matology are discussed.