CONTROLLED-RELEASE FORMULATIONS OF ALACHLOR BASED ON CALCIUM ALGINATE

Citation
Ab. Pepperman et Jcw. Kuan, CONTROLLED-RELEASE FORMULATIONS OF ALACHLOR BASED ON CALCIUM ALGINATE, Journal of controlled release, 34(1), 1995, pp. 17-23
Citations number
17
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
ISSN journal
01683659
Volume
34
Issue
1
Year of publication
1995
Pages
17 - 23
Database
ISI
SICI code
0168-3659(1995)34:1<17:CFOABO>2.0.ZU;2-D
Abstract
Granular controlled release formulations of alachlor were prepared fro m sodium alginate-kaolin-linseed oil-herbicide slurries dropped onto c alcium chloride to form spherical beads which were air-dried and evalu ated for release rates in a static water extraction. These formulation s gave considerably slower release of alachlor than a commercial formu lation and/or the alginate formulation without oil. Factors affecting the rate of release included aging of the dried formulation and the ra tio of oil/herbicide in the formulation. The size of the beads had no appreciable effect on the rate of release and several oils, including canola, corn, olive, safflower, peanut, soybean, and sunflower gave si milar release rates to linseed oil formulations for alachlor. The use of lignin in combination with alginate also produced a granular formul ation with reduced release rates.