ORAL CAPSAICIN PROVIDES TEMPORARY RELIEF FOR ORAL MUCOSITIS PAIN SECONDARY TO CHEMOTHERAPY RADIATION-THERAPY

Pain from oral mucositis afflicts from 40% to 70% of patients receivin g chemotherapy or radiation therapy. Current methods of clinical pain management (for example, topical anesthetics, systemic analgesics) hav e limited success. In a pilot study, we examined the ability of oral c apsaicin to provide temporary relief of oral mucositis pain. Capsaicin , the active ingredient in chili peppers, desensitizes some neurons an d has provided moderate pain relief when applied to the skin surface. Oral capsaicin in a candy (taffy) vehicle produced substantial pain re duction in 11 patients with oral mucositis pain from cancer therapy. H owever, this pain relief was not complete for most patients and was on ly temporary. Additional research is needed to fully utilize the prope rties of capsaicin desensitization and thus optimize analgesia.