PHOTODYNAMIC THERAPY OF PHOTOFRIN-II AND EXCIMER DYE-LASER ON EXPERIMENTAL-TUMORS

Photodynamic therapy (PDT) by combination of photofrin II and excimer dye laser was evaluated for its usefulness in experimental tumors, Hig h antitumor effects of PDT on sarcoma 180 solid type were obtained whe n PDT was performed with laser irradiation at an energy of 50 or 100 J /cm(2) (40 or 80 Hz, 4 mJ/pulse) 48 h after i.v. administration of pho tofrin II at a dose of 25 mg/kg. Under the same conditions, the antitu mor effects of PDT on murine Lewis lung carcinoma, human fibrosarcoma HT-1080 and human bladder transitional cell carcinoma KK-47 were also observed. These results suggest that clinical application of PDT with photofrin II and excimer dye laser might be useful.