A COMPUTER-SYSTEM FOR ANALYSIS AND INTEGRATED DESCRIPTION OF REGULATION OF THE MOLECULAR-GENETIC SYSTEM OF INTERFERON INDUCTION AND ACTION

A new theoretical approach to elaboration of an information-analytical integrated knowledge base containing data on regulation and function of biological systems is presented. The knowledge base incorporates. ( i) a reference database containing experimental data on the structural -functional organization of a biological system; (ii) a dynamic mathem atical model for analysis of the evolution of the system over time; an d (iii) an interpretation module of simulation results. Application of this approach to theoretical investigation of the interferon system i n the case of viral infection is discussed. The approach is specific i n that it uses mathematical modeling technology, which allows one to g enerate mathematical models of different degrees of complexity in the analysis of the diverse aspects of biological system behavior. This ap proach allows one not only to store and to treat available experimenta l data, but also to acquire new knowledge about the behavior of a biol ogical system. The proposed approach is implemented as a computer syst em for the IBM PC and compatibles.