BRAIN METASTASES - COMPARISON OF GADODIAMIDE INJECTION-ENHANCED MR-IMAGING AT STANDARD AND HIGH-DOSE, CONTRAST-ENHANCED CT AND NON-CONTRAST-ENHANCED MR-IMAGING

Citation
P. Akeson et al., BRAIN METASTASES - COMPARISON OF GADODIAMIDE INJECTION-ENHANCED MR-IMAGING AT STANDARD AND HIGH-DOSE, CONTRAST-ENHANCED CT AND NON-CONTRAST-ENHANCED MR-IMAGING, Acta radiologica, 36(3), 1995, pp. 300-306
Citations number
27
Categorie Soggetti
Radiology,Nuclear Medicine & Medical Imaging
Journal title
ISSN journal
02841851
Volume
36
Issue
3
Year of publication
1995
Pages
300 - 306
Database
ISI
SICI code
0284-1851(1995)36:3<300:BM-COG>2.0.ZU;2-E
Abstract
The aim was to compare the abilities of contrast-enhanced CT, non-cont rast-enhanced MR imaging and contrast-enhanced MR imaging using standa rd (0.1 mmol/kg b.w.) and high (0.3 mmol/kg b.w.) doses of Gadodiamide injection to detect brain metastases (i.e. blood-brain barrier damage ). Sixteen patients with at least 2 metastases found by CT were evalua ted by MR imaging using non-contrast-enhanced spin-echo, T1-weighted, T2-weighted sequences, and contrast-enhanced spin-echo T1-weighted seq uences at 2 dose levels. Gadodiamide injection was first given at the dose of 0.1 mmol/kg b.w. After imaging, another 0.2 mmol/kg b.w. was g iven, yielding a cumulative dose of 0.3 mmol/kg b.w. No contrast media -related adverse events were recorded. The images were evaluated openl y by one and blindly by 2 investigators and the number of metastases, size, delineation (open study) and diagnostic certainty (blind study) of each individual metastasis noted. High-dose MR imaging showed signi ficantly more and smaller metastases than any other examination, and g ave a higher diagnostic certainty. All high-dose images were superior to those with the standard dose MR imaging when compared blindly in pa irs. We conclude that spin-echo MR imaging with a high dose of Gadodia mide injection is an efficient way to improve the detection of brain m etastases, in particular of small ones.