STRUCTURAL-PROPERTIES OF ALPHA-FETOPROTEIN FROM HUMAN CORD SERUM - THE PROTEIN MOLECULE AT LOW PH POSSESSES ALL THE PROPERTIES OF THE MOLTEN GLOBULE

Authors
UVERSKY VN KIRKITADZE MD NARIZHNEVA NV POTEKHIN SA TOMASHEVSKI AY
Citation
Vn. Uversky et al., STRUCTURAL-PROPERTIES OF ALPHA-FETOPROTEIN FROM HUMAN CORD SERUM - THE PROTEIN MOLECULE AT LOW PH POSSESSES ALL THE PROPERTIES OF THE MOLTEN GLOBULE, FEBS letters, 364(2), 1995, pp. 165-167
Citations number
35
Categorie Soggetti
Biophysics,Biology
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
364
Issue
2
Year of publication
1995
Pages
165 - 167
Database
ISI
SICI code
0014-5793(1995)364:2<165:SOAFHC>2.0.ZU;2-9
Abstract
Structural studies of alpha-fetoprotein (AFP) from human cord serum ha ve shown that a decrease in pH to 3.1 leads to a considerable conforma tional rearrangement of the protein molecule. The acid form of AFP bel ongs to the class of denatured conformations and fulfills all the requ irements of the molten globule state. The possible functional role of such a transformation is discussed.