ALUMINUM, BETA-AMYLOID AND NONENZYMATIC GLYCOSYLATION

The non-enzymatic glycosylation of beta-amyloid is implicated in the a etiology of Alzheimer's disease, However, controversy surrounds the na ture of any involvement and a potential mechanism has not been fully e lucidated, We present evidence of an aluminium-induced aggregation of the A beta P(25-35) peptide and speculate that the mechanism of format ion of our ordered beta-amyloid aggregates might involve non-enzymatic glycosylation and/or site-specific crosslinking of beta-amyloid fibri ls by atomic aluminium.