SYNTHESIS OF PYRROLO[2,1-C][1,4]BENZODIAZEPINES VIA AN INTRAMOLECULARAZA-WITTIG REACTION - SYNTHESIS OF THE ANTIBIOTIC DC-81

Authors
MOLINA P DIAZ I TARRAGA A
Citation
P. Molina et al., SYNTHESIS OF PYRROLO[2,1-C][1,4]BENZODIAZEPINES VIA AN INTRAMOLECULARAZA-WITTIG REACTION - SYNTHESIS OF THE ANTIBIOTIC DC-81, Tetrahedron, 51(19), 1995, pp. 5617-5630
Citations number
29
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
51
Issue
19
Year of publication
1995
Pages
5617 - 5630
Database
ISI
SICI code
0040-4020(1995)51:19<5617:SOPVAI>2.0.ZU;2-2
Abstract
A new and efficient synthesis of the pyrrolo[2,1-c][1,4]benzodiazepine ring system has been carried out using, as a key step, an intramolecu lar aza Wittig reaction of the appropriately substituted N-(2-azidoben zoyl)pyrrolidine-2-carboxaldehydes. The parent unsubstituted PBD 4 and the natural product DC-81 have been prepared in the imine form in goo d overall yields.