SYNTHESIS OF BOTH THE ENANTIOMERS OF ASEANOSTATIN P5 (SARCINIC ACID),AN INHIBITOR OF MYELOPEROXIDASE RELEASE, AND 4 DIASTEREOMERS OF AGGRECERIDE-A, A PLATELET-AGGREGATION INHIBITOR
T. Kitahara et al., SYNTHESIS OF BOTH THE ENANTIOMERS OF ASEANOSTATIN P5 (SARCINIC ACID),AN INHIBITOR OF MYELOPEROXIDASE RELEASE, AND 4 DIASTEREOMERS OF AGGRECERIDE-A, A PLATELET-AGGREGATION INHIBITOR, Bioscience, biotechnology, and biochemistry, 59(1), 1995, pp. 78-82
Both the enantiomers of aseanostatin P5 (sarcinic acid), an inhibitor
of myeloperoxidase (MPO) release from human polymorphonuclear leukocyt
es (PMN), with high optical purity were synthesized by starting from (
S)-2-methylbutanol and methyl (S)-3-hydroxy-2-methylpropanoate. They w
ere converted to four diastereomers of aggreceride A, a platelet aggre
gation inhibitor.