SYNTHESIS OF BOTH THE ENANTIOMERS OF ASEANOSTATIN P5 (SARCINIC ACID),AN INHIBITOR OF MYELOPEROXIDASE RELEASE, AND 4 DIASTEREOMERS OF AGGRECERIDE-A, A PLATELET-AGGREGATION INHIBITOR

Authors
KITAHARA T AONO S MORI K
Citation
T. Kitahara et al., SYNTHESIS OF BOTH THE ENANTIOMERS OF ASEANOSTATIN P5 (SARCINIC ACID),AN INHIBITOR OF MYELOPEROXIDASE RELEASE, AND 4 DIASTEREOMERS OF AGGRECERIDE-A, A PLATELET-AGGREGATION INHIBITOR, Bioscience, biotechnology, and biochemistry, 59(1), 1995, pp. 78-82
Citations number
16
Categorie Soggetti
Biology,Agriculture,"Biothechnology & Applied Migrobiology","Food Science & Tenology
Journal title
Bioscience, biotechnology, and biochemistry → ACNP
ISSN journal
09168451
Volume
59
Issue
1
Year of publication
1995
Pages
78 - 82
Database
ISI
SICI code
0916-8451(1995)59:1<78:SOBTEO>2.0.ZU;2-W
Abstract
Both the enantiomers of aseanostatin P5 (sarcinic acid), an inhibitor of myeloperoxidase (MPO) release from human polymorphonuclear leukocyt es (PMN), with high optical purity were synthesized by starting from ( S)-2-methylbutanol and methyl (S)-3-hydroxy-2-methylpropanoate. They w ere converted to four diastereomers of aggreceride A, a platelet aggre gation inhibitor.