EFFECTS OF ALPHA-ARBUTIN AND BETA-ARBUTIN ON ACTIVITY OF TYROSINASES FROM MUSHROOM AND MOUSE MELANOMA

Authors
FUNAYAMA M ARAKAWA H YAMAMOTO R NISHINO T SHIN T MURAO S
Citation
M. Funayama et al., EFFECTS OF ALPHA-ARBUTIN AND BETA-ARBUTIN ON ACTIVITY OF TYROSINASES FROM MUSHROOM AND MOUSE MELANOMA, Bioscience, biotechnology, and biochemistry, 59(1), 1995, pp. 143-144
Citations number
6
Categorie Soggetti
Biology,Agriculture,"Biothechnology & Applied Migrobiology","Food Science & Tenology
Journal title
Bioscience, biotechnology, and biochemistry → ACNP
ISSN journal
09168451
Volume
59
Issue
1
Year of publication
1995
Pages
143 - 144
Database
ISI
SICI code
0916-8451(1995)59:1<143:EOAABO>2.0.ZU;2-6
Abstract
The effects of alpha- and beta-arbutin on the activity of tyrosinases from mushroom and mouse melanoma were examined. alpha a-Arbutin was sy nthesized from hydroquinone and starch using glucoside synthetase (GSa se). beta-Arbutin inhibited both tyrosinase activities from mushroom a nd mouse melanoma. alpha-Arbutin inhibited only the tyrosinase from mo use melanoma, 10 times as strongly as beta-arbutin. The IC50 of alpha- arbutin was 0.48 mM and its inhibitory mechanism was speculated to be mixed type inhibition, while that of beta-arbutin was noncompetitive.