Ke. Cullen et Kd. Sarge, CHARACTERIZATION OF HYPOTHERMIA-INDUCED CELLULAR STRESS-RESPONSE IN MOUSE-TISSUES, The Journal of biological chemistry, 272(3), 1997, pp. 1742-1746
Cells respond to adverse environmental conditions by expressing heat s
hock proteins, which serve to protect cells from harmful effects of th
e stress conditions. In this study we demonstrated that mice subjected
to whole body hypothermia induced the cellular stress response, resul
ting in the increased expression of hsp72 mRNA in brain, heart, kidney
, liver, and lung. We performed a detailed analysis of the major param
eters of the stress response and found that cold induction of hsp expr
ession is mediated by heat shock factor 1 (HSF1), which is also respon
sible for heat induction of the cellular stress response. However, the
re are differences in the mechanisms of HSF1 activation by hypothermia
versus hyperthermia, as hypothermia does not cause the hyperphosphory
lation of HSF1 that is characteristic of heat-activated HSF1.