HETEROTOPIC PREGNANCY FOLLOWING ADMINISTRATION OF HUMAN MENOPAUSAL GONADOTROPIN AND FOLLOWING IN-VITRO FERTILIZATION AND EMBRYO-TRANSFER - 2 CASE-REPORTS AND REVIEW OF THE LITERATURE

We report two cases of heterotopic (combined intra- and extra-uterine) pregnancy in women treated for infertility. In the first case the pat ient conceived following administration of human menopausal gonadotrop in. In the seventh week of gestation she had a spontaneous abortion an d in the eighth week required urgent laparotomy for acute abdomen due to the rupture of pregnant right tube. In the second case the patient conceived from IVF-ET; in the eighth week a salpingectomy was made. Th e intrauterine pregnancy continued regularly until term and the patien t was delivered of a healthy baby by caesarean section. We reviewed th e literature and we found that heterotopic pregnancy is an insidious d isease with a constant increase of incidence, especially in infertile women submitted to therapy for ovulation induction or assisted reprodu ctive techniques. All the patients who have risk factors should be sub mitted to careful controls in early pregnancy, including an ultrasound transvaginal scan.