FIRST-DOSE HYPOTENSION IN CARDIAC-INSUFFI CIENCY PATIENTS UNDER LISINOPRIL TREATMENT

The first dose response of 2.5 mg lisinopril was investigated in patie nts with cardiac insufficiency NYHA II - III with 24-hour blood pressu re measurements. In 428 patients 24-hour blood pressure profiles could be evaluated before and during the first treatment day. Symptomatic h ypotension occurred only in 1 patient, 2 other patients with hypotensi ve blood pressure values suffered from dizziness. Altogether, symptoma tic hypotension was observed in less than 1% of the patients. In 12.4% of the patients systolic blood pressure and in 16.8% diastolic blood pressure was lowered by more than 15%. In 9.6% both values were lowere d by more than 15%. Summarizing, these results demonstrate that a dose of 2.5 mg lisinopril is safe with regard to first dose hypotension in patients with cardiac insufficiency.