IMMUNOMODULATING EFFECTS OF THE NEW ANTIRHEUMATIC DRUG TENIDAP ON COLLAGEN-INDUCED

Authors
MATSUSHITA I MATSUNO H KADOWAKI KM OKADA C TSUJI H
Citation
I. Matsushita et al., IMMUNOMODULATING EFFECTS OF THE NEW ANTIRHEUMATIC DRUG TENIDAP ON COLLAGEN-INDUCED, International journal of immunopharmacology, 17(3), 1995, pp. 213-219
Citations number
16
Categorie Soggetti
Immunology,"Pharmacology & Pharmacy
Journal title
International journal of immunopharmacology → ACNP
ISSN journal
01920561
Volume
17
Issue
3
Year of publication
1995
Pages
213 - 219
Database
ISI
SICI code
0192-0561(1995)17:3<213:IEOTNA>2.0.ZU;2-M
Abstract
We investigated the in vivo action of the newly developed anti-rheumat ic agent tenidap, CP-66,248 (Pfizer Inc., New York), on arthritis in c ollagen-induced arthritic mice. The inhibitory effect of tenidap on th e development of arthritis was statistically more significant than pir oxicam. The serum anti-type II collagen antibody titer was markedly in hibited in the mice treated by tenidap. These results suggest that, un like NSAIDs, tenidap inhibits the progress of collagen-induced arthrit is through its immunomodulating effect.