The application of the one-dimensional theory of mass transport to the
derivation of mathematical formulas for clearances of a variety of me
mbrane mass exchangers, namely hemodialyzers, hemofilters, plasma sepa
rators, and the cascade filtration procedure, has been reviewed. The a
pplied theory predicts that clearances depend approximately on fluid i
nlet flow rates but not on concentrations, and with constant fluid flo
w rates, clearances are constant. Also, the application of device clea
rance in kinetic modeling has been discussed.