K. Duis et al., DELIVERY OF QUINOLONE ANTIBACTERIALS TO TURBOT, SCOPHTHALMUS-MAXIMUS (L), VIA BIOENCAPSULATION - QUANTIFICATION AND EFFICACY TRIAL, Journal of fish diseases, 18(3), 1995, pp. 229-238
The incorporation of the quinolone antibacterials oxolinic acid and sa
rafloxacin into Artemia fransciscana and subsequently into turbot, Sco
phthalmus maximus (L.), was quantified, and the therapeutic efficacy o
f the bioencapsulated drugs against challenge with Vibrio anguillarum
8587 was investigated. Five-week-old turbot were fed for 10 days with
Artemia enriched with either oxolinic acid or sarafloxacin. Therapeuti
c concentrations were reached with both drugs (11.8 mu g oxolinic acid
per gram fresh weight; 1.8 mu g sarafloxacin per gram fresh weight).
Both treatments proved effective against challenge, with V. anguillaru
m-specific mortality rates of 6 and 14% in the oxolinic acid and saraf
loxacin treated groups, respectively, compared with 75% in the infecte
d control. However, incorporation of the drug by brine shrimp was extr
emely low (<1%), and therefore, bioencapsulation cannot be considered
as an appropriate method to reduce impact on the environment.