THE EFFECTS OF AMPA-INDUCED LESIONS OF THE MEDIAL SEPTUM AND VERTICALLIMB NUCLEUS OF THE DIAGONAL BAND OF BROCA ON SPATIAL DELAYED-NONMATCHING-TO-SAMPLE AND SPATIAL-LEARNING IN THE WATER MAZE
Gm. Mcalonan et al., THE EFFECTS OF AMPA-INDUCED LESIONS OF THE MEDIAL SEPTUM AND VERTICALLIMB NUCLEUS OF THE DIAGONAL BAND OF BROCA ON SPATIAL DELAYED-NONMATCHING-TO-SAMPLE AND SPATIAL-LEARNING IN THE WATER MAZE, European journal of neuroscience, 7(5), 1995, pp. 1034-1049
These experiments investigated in the rat the impact on spatial delaye
d non-matching to sample and on acquisition of the Morris water maze o
f (i) AMPA-induced lesions of the medial septal nucleus, which produce
d a marked reduction of hippocampal choline acetyltransferase activity
and acetylcholine levels (measured using in vivo dialysis) together w
ith lesser reductions in cholinergic markers in the cingulate cortex a
nd (ii) similar AMPA-induced lesions of the vertical limb nucleus of t
he diagonal band of Broca (vDB), which produced more marked reductions
in cholinergic markers in the cingulate cortex than in the hippocampu
s. Medial septal lesions produced a delay-dependent deficit in spatial
working memory, while lesions of the vDB resulted in a delay-independ
ent performance deficit. In addition, rats with vDB lesions adopted bi
ased response strategies during the imposition of long delays. Neither
lesion significantly affected the acquisition of a spatial reference
memory task, the Morris water maze, The results are discussed in terms
of cholinergic- and GABAergic-dependent functions of the hippocampal
formation and cingulate cortex in spatial short-term and reference mem
ory.