C. Cativiela et al., CHIRAL 2-CYANO ESTERS AS SYNTHETIC INTERMEDIATES IN THE SYNTHESIS OF R-ALPHA-METHYLVALINE AND S-ALPHA-METHYLVALINE, Tetrahedron, 51(20), 1995, pp. 5921-5928
A divergent stereoselective synthesis of R and S alpha-methylvaline fr
om (2RS) (1S,2R,4R)-10-dicyclohexylsulfamoylisobornyl 2-cyano-3-methyl
butanoate has been developed.