DISSEMINATED INTRAVASCULAR COAGULATION ASSOCIATED WITH GRANULOCYTE-COLONY-STIMULATING FACTOR THERAPY IN A CHILD WITH HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION

We report a case of disseminated intravascular coagulopathy, apparentl y caused by exposure to granulocyte colony-stimulating factor (G-CSF), The medical records of patients treated for more than 30 consecutive days with subcutaneously administered G-CSF were reviewed for the occu rrence of thrombocytopenia or coagulation abnormalities, New-onset thr ombocytopenia with a platelet count less than 100 X 10(9) cells/L (<10 0,000 cells/mm(3)) developed in 9 of 23 patients (39%) after a median of II weeks of treatment with G-CSF at dosages between 1 and 10 mu g/k g per day.