PERMANENT HETEROTOPIC OSSIFICATION AT THE INJECTION SITE AFTER DIPHTHERIA-TETATNUS-PERTUSSIS IMMUNIZATIONS IN CHILDREN WHO HAVE FIBRODYSPLASIA OSSIFICANS PROGRESSIVA

Authors
LANCHONEY TF COHEN RB ROCKE DM ZASLOFF MA KAPLAN FS
Citation
Tf. Lanchoney et al., PERMANENT HETEROTOPIC OSSIFICATION AT THE INJECTION SITE AFTER DIPHTHERIA-TETATNUS-PERTUSSIS IMMUNIZATIONS IN CHILDREN WHO HAVE FIBRODYSPLASIA OSSIFICANS PROGRESSIVA, The Journal of pediatrics, 126(5), 1995, pp. 762-764
Citations number
14
Categorie Soggetti
Pediatrics
Journal title
The Journal of pediatrics → ACNP
ISSN journal
00223476
Volume
126
Issue
5
Year of publication
1995
Part
1
Pages
762 - 764
Database
ISI
SICI code
0022-3476(1995)126:5<762:PHOATI>2.0.ZU;2-D
Abstract
In patients who have fibrodysplasia ossificans progressiva, routine ch ildhood diphtheria-tetanus-pertussis immunizations administered by int ramuscular injection caused a significant risk of permanent heterotopi c ossification at the site of injection (p < 10(-8)), whereas measles- mumps-rubella immunizations administered by subcutaneous injection pos ed no significant risk, Intramuscular injections should be avoided, if possible, once a diagnosis of fibrodysplasia ossificans progressiva h as been established.