EFFECT OF TIMING OF FOOD ON ABSORPTION OF CEFPODOXIME PROXETIL

The effect of a high-fat meal and the timing of this meal on the absor ption of a 400-mg oral dose of cefpodoxime proxetil was evaluated in 2 0 healthy, adult, male volunteers in a four-way crossover study. The a rea under the plasma concentration-time curve, peak plasma concentrati on, and urinary recovery were significantly greater (P = .0001) after administration of cefpodoxime proxetil tablets with and 2 hours after a meal relative to dosing under fasted conditions or 1 hour before a m eal. The time to peak concentration did nor differ significantly among treatments, which suggests that food did not affect the rate of drug absorption. These results indicate that absorption of cefpodoxime prox etil is enhanced when tablets are taken with food or shortly after a m eal.