ALPHA-1-ACID GLYCOPROTEIN CONCENTRATION AND THE PROTEIN-BINDING OF DISOPYRAMIDE IN HEALTHY-SUBJECTS

Age- and gender-related changes in serum alpha(1)-acid glycoprotein (A AG) concentration and the serum protein binding of disopyramide were e xamined after intensive medical examination. Based on the clinical che mistry tests over 51 points, 245 subjects were diagnosed as healthy an d 71 subjects (22.5%) revealed an abnormal value for at least one item , In the healthy subjects, serum AAG concentration in men was signific antly higher than in women (men, 0.78 +/- 0.18 mg/mL, mean +/- SD; wom en, 0.67 +/- 0.16 mg/mL. In contrast, there were no significant differ ences in the AAG concentration between age groups for men and women an d in the unbound fraction of disopyramide. Gender changes AAG concentr ation. Age, however, does not change AAG concentration and the protein binding of the basic drug.