BUSPIRONE ANALOGS AS LIGANDS OF THE 5-HT1A RECEPTOR .1. THE MOLECULAR-STRUCTURE OF BUSPIRONE AND ITS 2 ANALOGS

An interdisciplinary (X-ray, H-1 and C-13 NMR, IR, and theoretical qua ntum mechanical) study on the potent 5-HT1A receptor ligand buspirone (1) and its two structural analogues, mesmar nolinyl)-1-piperazinyl]bu tyl]-2,6-piperidinedione) (2) and kaspar iperazinyl]butyl]-8-azaspiro[ 4.5]decane-7,9-dione) (3), has been reported. The results have shown t hat buspirone-like molecules should appear in an extended rod-shape fo rm, possessing several potential interaction sites with the receptor.