ACANTHOLYTIC EPIDERMOLYSIS-BULLOSA

Background: We describe a new variant of inherited epidermolysis bullo sa and elucidate the clinical, histologic, and ultrastructural feature s of this condition. Observations: This form of epidermolysis bullosa displays an autosomal dominant inheritance pattern, is characterized b y acral bullae, and histologically demonstrates suprabasal clefting wi th acantholysis. Ultrastructural findings are nonspecific but reminisc ent of those observed in benign familial pemphigus. Conclusion: Acanth olytic epidermolysis bullosa is a rare but distinct clinicopathologic entity that warrants inclusion in the nosologic classification of epid ermolysis bullosa.