P. Valensi et al., THE EFFECTS OF METFORMIN ON THE CAPILLARY-PERMEABILITY TO ALBUMIN IN WOMEN PATIENTS WITH CYCLIC EDEMA, Angiology, 46(5), 1995, pp. 401-408
Citations number
26
Categorie Soggetti
Medicine, General & Internal","Cardiac & Cardiovascular System","Peripheal Vascular Diseas
An experimental work has suggested the efficacy of metformin, an oral
antidiabetic agent, on capillary permeability. This agent has been tes
ted in 10 women patients with cyclic edema, 7 of them being obese. The
capillary permeability to albumin studied by an isotope test derived
from Landis's method was initially increased. After a mean of six-week
s of treatment the albumin retention and an index demonstrating the in
terstitial protein elimination through the lymph route were significan
tly improved. Concomitantly, the swelling feelings were reduced in 8 c
ases and the lower limb edema had decreased or disappeared in 8 of 9 p
atients who initially presented these symptoms. The effects of metform
in are beneficial and have been observed to be independent of glycemic
change. The results suggest a special effect of this agent on the mic
rocirculation, Nevertheless, a controlled study is required.