A twenty-nine-year old woman with a history of rheumatic fever and bot
h mitral and tricuspid valve prolapse (without cardiac effects on the
echocardiogram) presented with Streptococcus viridans infective endoca
rditis of both the tricuspid and mitral valves at seventeen weeks' ges
tation. Twelve weeks before admission she underwent a dental curettage
and received presumably adequate antibiotic prophylaxis. The present
case was successfully managed by means of aggressive antibiotic therap
y appropriate for endocarditis, with adequate and appropriate monitori
ng of minimal inhibitory concentration and peak and trough levels. Thi
s case exhibits the appropriate management in the three phases of ther
apy for valvular disease, ie prevention, treatment, and subsequent pre
vention of sequelae, prior to vaginal delivery in a patient with endoc
arditis. The pregnancy resulted in a term vaginal delivery, without ma
ternal or fetal morbidity.