TUBERCULIN SENSITIVITY AND HIV-1 STATUS OF PATIENTS ATTENDING A SEXUALLY-TRANSMITTED DISEASES CLINIC IN LUSAKA, ZAMBIA - A CROSS-SECTIONAL STUDY

A cross-sectional study to estimate the prevalence of latent tuberculo sis (TB) in a group of Zambians at high risk of human immunodeficiency virus type 1 (HIV-1) infection and to examine the effect of HIV-1 inf ection on the tuberculin response was conducted in the University Teac hing Hospital in Lusaka, Zambia during July to September 1990. Patient s were selected from those presenting to the out-patient clinic for fi rst referral with either sexually transmitted or skin diseases. 268 ad ults were included in the study; 158 (59%; 95% confidence interval [CI ]=53-65%) were HIV-1 antibody positive. Of 82 HIV-1 negative participa nts who returned for Mantoux skin test reading, 51 (62%; 95% CI=57-67% ) had a positive test reaction (diameter greater than or equal to 10 m m) after receiving 2 units of RT-23 tuberculin. Of 106 HIV-1 positive participants who returned, only 32 (30%; 95% CI=26-34%) had a diameter greater than or equal to 10 mm. Nine (28%) of the HIV-1 positive and Mantoux positive participants had large reactions greater than or equa l to 30 mm, compared to 4 (8%) of the HIV-1 negative, Mantoux positive participants (P=0.03). Results in the HIV-1 negative group indicated a prevalence of latent TB of 62% in this population. HIV-1 infection w as associated with a much higher frequency, of negative response to tu berculin and with a few large skin test responses. Thus, in population s where HIV seropositivity is high, Mantoux skin tests cannot be used to assess those with latent TB who might benefit from chemoprophylaxis .