K. Koike et al., FREQUENT NATURAL-KILLER-CELL ABNORMALITY IN CHILDREN IN AN AREA HIGHLY CONTAMINATED BY THE CHERNOBYL ACCIDENT, International journal of hematology, 61(3), 1995, pp. 139-145
Since January 1991, we have been performing thyroid surveys and hemato
logic and immunologic screening on children in Chechersk, Belarus, a c
ity situated in one of the areas most seriously contaminated with high
levels of radionuclides after the Chernobyl accident. Ten children se
lected from 713 children because of goiter did not show a decrease in
humoral immunity or in the number and function of T cells. By contrast
, natural killer (NK) cell activity against K562 cells was depressed i
n 4 of these 10 children. The clinical and laboratory findings indicat
ed that previously reported diseases with NK cell dysfunction could be
excluded, A comparative analysis of NK cell activity in children from
areas with and without high Cs-137 levels revealed a high frequency o
f abnormal NK cell activity only in children from the area contaminate
d by radioactive fallout. In addition, there was no correlation betwee
n NK cell activity and NK cell number as percentage in the children fr
om the area with high Cs-137 levels. Neither activity nor number of NK
cells was correlated with the body content of Cs-137. Thus, the frequ
ent abnormality of NK cell function may not have been due to actual in
ternal exposure to the long-lived radionuclide.